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Despite its initially identified neurogenic output, the SEZ is now known to also generate oligodendrocyte progenitor cells (OPCs) from Olig2-expressing transit-amplifying progenitors in the niche (Ta Ps/ also known as type C cells).
During early post-natal stages stem and progenitor cells of the SEZ generate oligodendrocyte progenitors that migrate in a wide range of brain areas, including the corpus callosum, the cerebral cortex and the striatum, where they give rise to myelinating oligodendrocytes (Zerlin et al., 1995).
After the SEZ assumes its mature structure (Alves et al., 2002) and switches to an adult phenotype (Jablonska et al., 2007), the adult niche-derived OPCs seem to migrate shorter distances, such as to the closely located corpus callosum (Cayre et al., 2006; Menn et al., 2006) (Figure 1), but in response to demyelination can migrate further afield such as to the striatum (Capilla-Gonzalez et al., 2013b).
However, currently little is known about the characteristics of niche-derived adult OPCs and the functions they might serve. Oligodendrogenesis from niche and parenchymal progenitors in the adult corpus callosum. doi: 10.1038/nn1620 Pubmed Abstract | Pubmed Full Text | Cross Ref Full Text Kujuro, Y., Suzuki, N., and Kondo, T. Esophageal cancer-related gene 4 is a secreted inducer of cell senescence expressed by aged CNS precursor cells.
So enjoy our service, but please visit our sponsors so they keep paying us. Adult Cyber Dating.net, the Official Adult Cyber Dating Website.I read a really enlightening article on the challenges that "adult" startups face when they try to do things the legitimate way (as opposed to using underhanded, duplicitous, and/or legally questionable tactics).It's rather sad that these startups are essentially punished for not wanting to deceive their business partners about what they do.Cellular integration and survival depends on sensory olfactory inputs (i.e., exposure to new odors), as well as on the ability of these neural progenitors to form the appropriate synaptic connections with other cells (Mouret et al., 2008).
This supply of new neurons to the OB is not only necessary for olfactory learning and memory but also for successful social and mating encounters in rodents (Oboti et al., 2011).
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